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Atoreza (Brand name: Vytorin)

  • €0.75
  • Brand name: Vytorin
  • Disponibilidad: En stock
  • Ingrediente activo: simvastatin
Atoreza es utilizado para tratar el colesterol alto junto con una dieta que contribue a la reducción del colesterol.
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30 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €2.28 €68.40
60 píldoras €1.84 €136.80 €110.25
90 píldoras €1.69 €205.19 €152.10
120 píldoras €1.62 €273.59 €193.95
180 píldoras €1.54 €410.39 €277.64
270 píldoras €1.49 €615.58 €403.20
20 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.27 €38.21
60 píldoras €0.99 €76.43 €59.34
90 píldoras €0.89 €114.64 €80.45
120 píldoras €0.85 €152.85 €101.58
180 píldoras €0.80 €229.28 €143.81
270 píldoras €0.77 €343.92 €207.17
360 píldoras €0.75 €458.56 €270.54

Drug Name

Atoreza (Ezetimibe/Simvastatin) 

Drug Uses

Atoreza (Ezetimibe/Simvastatin) is used for reducing total cholesterol, LDL cholesterol, and triglycerides and for increasing HDL cholesterol.

Atoreza is available in a 20 mg dosage ( 10 mg of ezetimibe and 10 mg of simvastatin) and in a 30 mg dosage (10 mg of ezetimibe, and 20 mg of simvastatin).

How to use

The recommended dose range of Atoreza is 10/10 mg to 10/80 mg, and it is administered once daily in the evening with or without food. Therapy  is usually initiated with 10/20 mg daily, but individuals who need more than a 55% reduction in LDL cholesterol can be started on 10/40 mg daily. 

Drug Class and Mechanism

Atoreza is a combination of ezetimibe (Zetia) and simvastatin (Zocor) that is used for treating high levels of cholesterol in the blood. Atoreza reduces total cholesterol and low density lipoprotein cholesterol while it increases high density lipoprotein cholesterol. The ezetimibe component of Atoreza lowers blood cholesterol by blocking the absorption of cholesterol, including dietary cholesterol, from the intestine. It does not affect the absorption of triglycerides. The simvastatin component of Atoreza belongs to a class of drugs called HMG-CoA reductase inhibitors, commonly called 'statins'. Statins reduce cholesterol by blocking an enzyme in the liver (HMG-CoA reductase) that produces cholesterol. Statins lower total and LDL cholesterol in the blood as well as triglycerides. They also increase HDL cholesterol. LDL cholesterol is believed to be an important cause of coronary artery disease. Lowering LDL cholesterol levels slows and may even reverse coronary artery disease. Raising HDL cholesterol levels also may slow down coronary artery disease. Atoreza was approved by the FDA in July, 2004. 

Missed Dose

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. 

Storage

Atoreza should be stored at room temperature, 20-25 degrees C (68-77 degrees F).

Warnings/Precautions

Before taking ezetimibe/simvastatin, tell your doctor or pharmacist if you think you are allergic to it; or to other drugs called 'statins'; or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: active liver disease. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease, history of liver disease, kidney disease, underactive thyroid (hypothyroidism), poorly controlled diabetes, alcohol use. Developing severe muscle damage, which is rare, can sometimes lead to serious kidney problems (see the Side Effects section in this handout). This medication is usually temporarily stopped if you have any condition which can increase your risk of developing kidney problems. Before you stop taking your medication, notify your doctor immediately if you have any of the following conditions: major surgery, trauma, serious illness (e.g., sepsis or severe metabolic, endocrine, or electrolyte disorders), very low blood pressure, uncontrolled seizures. Limit alcoholic beverages. Daily use of alcohol may increase your chance for serious side effects. Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects, especially muscle damage. This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. It is recommended that young girls and women of child-bearing age use effective birth control to prevent pregnancy while taking this drug. One of these drugs (simvastatin) may cause harm to your unborn child. It is not known if either drug passes into breast milk. A drug similar to simvastatin passes into breast milk, and because of this drug's potential risk of undesirable effects on a nursing infant, breast-feeding is not recommended while using ezetimibe/simvastatin. Consult your doctor before breast-feeding.

Possible Side Effects

Headache may occur. If this effect persists or worsens, notify your doctor or pharmacist promptly. This drug can sometimes cause muscle damage. Although uncommon, this may lead to very serious muscle damage called rhabdomyolysis, which in rare cases can be fatal. Seek immediate medical attention if you develop: muscle pain/tenderness/weakness (especially with fever or unusual tiredness). Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: yellowing eyes and skin, dark urine, severe fatigue, stomach/abdominal pain, persistent nausea, change in the amount of urine. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. 

More Information

Do not share this medication with others. Laboratory and/or medical tests (e.g., blood cholesterol levels, liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. For best results, this product should be used along with exercise, a low-cholesterol or low-fat diet, and a weight-loss program if you are overweight. Also to help reduce your risk of heart attacks and strokes, check your blood pressure regularly, seek medical treatment if your blood pressure is high, and stop smoking. Consult your doctor for more details.

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Type Small Molecule
Accession Number DB00973  (APRD00619)
Groups Approved
Synonyms
  • Ezedoc
  • Ezetimiba
  • Ezetimibum
  • Ezetrol
UNII EOR26LQQ24
CAS number 163222-33-1
Weight Average: 409.4252
Monoisotopic: 409.148949953
Chemical Formula C24H21F2NO3
InChI
InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
IUPAC Name
(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
Protein binding

Ezetimibe and ezetimibe-glucuronide are >90% bound to human plasma proteins [Label]. The mean in vitro protein binding ranged from 99.5% to 99.8% for ezetimibe and 87.8% to 92.0% for ezetimibe-glucuronide [3].

Toxicity

Oral LD50 and intraperitoneal LD50 in rat were >2000 mg/kg [MSDS]. Estimated oral LD50 values in mouse and dog are >5000 mg/kg and >3000 mg/kg, respectively [MSDS]. One case of accidental overdose occurred in clinical studies in one female patient with homozygous sitosterolemia receiving 120 mg/day for 28 days with no reported clinical or laboratory adverse events [Label]. In case of overdose, symptomatic treatment is recommended [Label].

Half life

Both ezetimibe and ezetimibe-glucuronide display an approximate half-life of 22 hours [Label].

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