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Siglita (Brand name: Januvia)

  • €3.75
  • Brand name: Januvia
  • Disponibilidad: En stock
  • Ingrediente activo: Sitagliptin
Siglita es utilizada para tratar diabetes de tipo 2 en pacientes que no pueden controlar sus niveles de azúcar en sangre con dieta y ejercicio.

100 mg
Nombre del producto Por píldora Por paquete  
10 píldoras €6.70 €66.98
20 píldoras €5.04 €133.96 €100.81
30 píldoras €4.49 €200.94 €134.63
40 píldoras €4.21 €267.92 €168.46
60 píldoras €3.94 €401.88 €236.11
90 píldoras €3.75 €602.83 €337.58

INDICATIONS 

Siglita is used for treating type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise alone. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines. Siglita is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the amount of insulin released by your body, and decreasing the amount of sugar made by your body.

INSTRUCTIONS

Use Siglita as directed by your doctor.

  • Take Siglita by mouth with or without food.
  • Take Siglita on a regular schedule to get the most benefit from it.
  • Continue to take Siglita even if you feel well. Do not miss any doses.
  • If you miss a dose of Siglita, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Siglita.

STORAGE

Store Siglita at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Siglita out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Sitagliptin.

SAFETY INFORMATION

Do NOT use Siglita if:

  • you are allergic to any ingredient in Siglita
  • you have type 1 diabetes
  • you have high blood ketone levels (diabetic ketoacidosis).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Siglita. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems
  • if you have a history of inflammation of the pancreas (pancreatitis).

Some medicines may interact with Siglita. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Siglita.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Siglita may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Follow the diet and exercise program given to you by your health care provider. Proper diet, regular exercise, and regular blood sugar testing are important for best results with Siglita.
  • Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Siglita exactly as prescribed, tell your doctor.
  • It may be harder to control your blood sugar during times of stress such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor.
  • Siglita usually does not cause low blood sugar. However, low blood sugar may occur when it is used along with certain other medicines for diabetes (eg, sulfonylureas). Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets, gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
  • Lab tests, including fasting blood glucose, glycosylated hemoglobin, and kidney function, may be performed while you use Siglita. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Siglita with caution in the elderly; they may be more sensitive to its effects.
  • Siglita should be used with extreme caution in children younger 18 years; safety and effectiveness in these children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Siglita while you are pregnant. It is not known if Siglita is found in breast milk. If you are or will be breast-feeding while you use Siglita, check with your doctor. Discuss any possible risks to your baby.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; headache; nausea; runny or stuffy nose; sore throat; upper respiratory infection; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); fever, chills, or persistent sore throat; red, blistered, swollen, or peeling skin; symptoms of pancreas inflammation (eg, severe stomach or back pain with nausea or vomiting, stomach tenderness or swelling, fast heartbeat, dizziness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Para no experimentar las reacciones no deseadas y los efectos secundarios hemos de tener en cuenta las contraindicaciones, advertencias y las precauciones. Aun así, algunos pacientes hipersensibles podrían experimentar reacciones negativas de diferente grado que vamos a enumerar. Busque asistencia médica sin hesitar en el momento en que haya notado los siguientes efectos secundarios que enumeraremos más abajo y póngase en contacto con algún médico o especialista médico online para eliminar el riesgo de consecuencias graves:

More Common

  • Body aches or pain
  • cough
  • difficulty with breathing
  • ear congestion
  • fever
  • loss of voice
  • muscle aches
  • sneezing
  • sore throat
  • stuffy or runny nose

Less Common

  • Diarrhea
  • stomach pain

Incidence Not Known

  • Blistering, peeling, loosening of the skin
  • diarrhea
  • hives or welts, itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • redness of the skin
  • severe joint pain
  • sores, ulcers, or white spots in the mouth or on the lips
  • vomiting
Type Small Molecule
Accession Number DB01261  (DB07214)
Groups Approved, Investigational
Synonyms
  • (2R)-4-OXO-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
  • MK-0431
  • Sitagliptan
  • Sitagliptin phosphate
  • Sitagliptina
  • Sitagliptine
  • Sitagliptinum
UNII QFP0P1DV7Z
CAS number 486460-32-6
Weight Average: 407.3136
Monoisotopic: 407.118079357
Chemical Formula C16H15F6N5O
InChI
InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
IUPAC Name
(3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Protein binding

The fraction of sitagliptin reversibly bound to plasma proteins is low (38%).

Toxicity Not Available
Half life

12.4 hours

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