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Sclerace (Brand name: Altace)

  • €0.59
  • Brand name: Altace
  • Disponibilidad: En stock
  • Ingrediente activo: Ramipril
Sclerace es utilizado para tratar la presión arterial alta o reducir el riesgo de ataque cardiaco, accidente cerebrovascular y la muerte de ciertos pacientes.
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10 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.24 €37.33
60 píldoras €1.01 €74.66 €60.38
90 píldoras €0.93 €111.99 €83.44
120 píldoras €0.89 €149.33 €106.49
180 píldoras €0.85 €223.99 €152.59
270 píldoras €0.82 €335.98 €221.74
2.5 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €0.95 €28.56
60 píldoras €0.78 €57.12 €46.84
90 píldoras €0.72 €85.68 €65.12
120 píldoras €0.69 €114.24 €83.39
180 píldoras €0.67 €171.36 €119.95
270 píldoras €0.65 €257.04 €174.78
360 píldoras €0.64 €342.72 €229.61
1.25 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €0.88 €26.31
60 píldoras €0.72 €52.63 €43.16
90 píldoras €0.67 €78.94 €60.00
120 píldoras €0.64 €105.26 €76.84
180 píldoras €0.61 €157.89 €110.52
270 píldoras €0.60 €236.83 €161.04
360 píldoras €0.59 €315.77 €211.57
5 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.13 €33.77
60 píldoras €0.92 €67.54 €55.39
90 píldoras €0.86 €101.31 €77.00
120 píldoras €0.82 €135.08 €98.61
180 píldoras €0.79 €202.62 €141.84
270 píldoras €0.77 €303.93 €206.67
360 píldoras €0.75 €405.24 €271.51

INDICATIONS

Sclerace is used for treating high blood pressure or decreasing the risk of heart attack, stroke, and death in certain patients. It may be used alone or with other medicines. It is used along with other medicines to manage heart failure and improve survival after a heart attack. Sclerace is an angiotensin-converting enzyme (ACE) inhibitor. It works by relaxing blood vessels. This helps to lower blood pressure.

INSTRUCTIONS 

Use Sclerace as directed by your doctor.

  • Take Sclerace by mouth with or without food.
  • Swallow this tablet whole unless your doctor tells you otherwise.
  • Continue to take Sclerace even if you feel well. Do not miss any dose.
  • If you miss a dose of Sclerace, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sclerace.

STORAGE

Store Sclerace between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Sclerace out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Ramipril.

SAFETY INFORMATION

Do NOT use Sclerace if:

  • you are allergic to any ingredient in Sclerace
  • you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness) caused by treatment with an ACE inhibitor
  • you are in your second or third trimester of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Sclerace. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are able to become pregnant
  • if you have a history of heart problems (eg, aortic stenosis, heart failure), blood vessel problems, blood flow problems, bone marrow problems, kidney problems, certain liver problems (eg, ascites, cirrhosis), or diabetes
  • if you have a history of angioedema, stroke, or recent heart attack, or you have had a kidney transplant
  • if you have an autoimmune disease (eg, lupus, rheumatoid arthritis, scleroderma)
  • if you are dehydrated or have low blood volume, high blood potassium levels, or low blood sodium levels, or if you are on a low-salt (sodium) diet
  • if you are receiving treatments to reduce sensitivity to bee stings
  • if you are on dialysis or are scheduled to have major surgery.

Some medicines may interact with Sclerace. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased
  • Aldosterone blockers (eg, eplerenone), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), potassium-sparing diuretics (eg, spironolactone, triamterene), potassium supplements, or trimethoprim because the risk of high blood potassium levels may be increased
  • Certain gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur
  • Lithium or thiopurines (eg, azathioprine) because the risk of their side effects may be increased by Sclerace.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sclerace may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Sclerace may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Sclerace with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Sclerace may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Sclerace may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.
  • Sclerace may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.
  • Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.
  • Rarely, Sclerace may lower the ability of your body to fight infection. This risk may be greater if you have certain other health problems (eg, kidney problems, collagen vascular disease). Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Tell your doctor or dentist that you take Sclerace before you receive any medical or dental care, emergency care, or surgery.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel 'normal.' Tell your doctor if you develop any new symptoms.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • Diabetes patients - Sclerace may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests, including blood pressure, blood electrolyte levels, heart function, or kidney or liver function, may be performed while you use Sclerace. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Sclerace with caution in the elderly; they may be more sensitive to its effects.
  • Sclerace should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: Sclerace may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Sclerace is found in breast milk. Do not breastfeed while taking Sclerace.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Cough; dizziness; headache; tiredness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the hands, eyes, mouth, face, lips, or tongue; hoarseness); chest pain; dark urine; decreased urination; difficulty swallowing; fainting; infection (eg, fever, chills, persistent sore throat); irregular heartbeat; seizures; stomach pain (with or without nausea or vomiting); symptoms of low blood pressure (eg, fainting, severe dizziness, lightheadedness); yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Para no experimentar las reacciones no deseadas y los efectos secundarios hemos de tener en cuenta las contraindicaciones, advertencias y las precauciones. Aun así, algunos pacientes hipersensibles podrían experimentar reacciones negativas de diferente grado que vamos a enumerar. Busque asistencia médica sin hesitar en el momento en que haya notado los siguientes efectos secundarios que enumeraremos más abajo y póngase en contacto con algún médico o especialista médico online para eliminar el riesgo de consecuencias graves:

Rare

  • Seizures
  • unexplained bleeding or bruising
  • Feeling of constant movement of self or surroundings
  • muscle pain or stiffness
  • sensation of spinning
  • stomach pain
  • weight loss

More Common

  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness
  • Cough

Less Common

  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • chills
  • cloudy urine
  • cold sweats
  • decrease in urine output or decrease in urine-concentrating ability
  • diarrhea
  • fainting
  • fast or irregular heartbeat
  • shortness of breath
  • Nausea
  • vomiting
Type Small Molecule
Accession Number DB00178  (APRD00009)
Groups Approved
Synonyms
  • (2S-(1(R*(r*)),2alpha,3abeta,6abeta))-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid
  • Altace (tn)
  • Ramipril
  • Ramiprilum
  • Tritace
UNII L35JN3I7SJ
CAS number 87333-19-5
Weight Average: 416.5106
Monoisotopic: 416.231122144
Chemical Formula C23H32N2O5
InChI
InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
IUPAC Name
(2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Protein binding

Protein binding of ramipril is about 73% and that of ramiprilat about 56%.

Toxicity

Symptoms of overdose may include excessive peripheral vasodilation (with marked hypotension and shock), bradycardia, electrolyte disturbances, and renal failure. The most likely adverse reactions are symptoms attributable to its blood-pressure lowing effect. May cause headache, dizziness, asthenia, chest pain, nausea, peripheral edema, somnolence, impotence, rash, arthritis, and dyspnea. LD50 = 10933 mg/kg (orally in mice).

Half life

Plasma concentrations of ramiprilat decline in a triphasic manner. Initial rapid decline represents distribution into tissues and has a half life of 2-4 hours. The half life of the apparent elimination phase is 9-18 hours and that of the terminal elimination phase is > 50 hours. Two elimination phases occur as a result of ramiprilat's potent binding to ACE and slow dissociation from the enzyme. The half life of ramiprilat after multiple daily doses (MDDs) is dose-dependent, ranging from 13-17 hours with 5-10 mg MDDs to 27-36 hours for 2.5 mg MDDs.

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