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Slow Zem (Brand name: Cardizem)

  • €0.35
  • Brand name: Cardizem
  • Disponibilidad: En stock
  • Ingrediente activo: Diltiazem
Slow Zem es utilizado para el tratamiento de la taquicardia supraventricular, una arritmia del corazón.
Otros nombres de Slow Zem (Brand name: Cardizem): Diltiazem  
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180 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.89 €56.73
60 píldoras €1.21 €113.47 €72.62
90 píldoras €0.98 €170.20 €88.51
120 píldoras €0.87 €226.94 €104.39
180 píldoras €0.76 €340.40 €136.16
270 píldoras €0.68 €510.61 €183.83
360 píldoras €0.64 €680.81 €231.48
120 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.19 €35.62
60 píldoras €0.90 €71.23 €53.75
90 píldoras €0.80 €106.85 €71.88
120 píldoras €0.75 €142.47 €90.01
180 píldoras €0.70 €213.70 €126.28
270 píldoras €0.67 €320.56 €180.67
360 píldoras €0.65 €427.41 €235.09
60 mg
Nombre del producto Por píldora Por paquete  
60 píldoras €0.63 €37.59
90 píldoras €0.52 €56.39 €46.46
120 píldoras €0.46 €75.18 €55.34
180 píldoras €0.41 €112.78 €73.08
270 píldoras €0.37 €169.16 €99.69
360 píldoras €0.35 €225.55 €126.31

INDICATIONS

Slow Zem is used for treating supraventricular tachycardia, a rhythm disturbance of the heart. It is also used for controlling heart rate response to other rhythm disturbances, specifically, atrial fibrillation and flutter. Slow Zem is a calcium channel blocker. It works by slowing the electrical conduction in the heart, slowing heart rate, and/or normalizing heart rhythm.

INSTRUCTIONS 

Use Slow Zem as directed by your doctor.

  • Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
  • Your doctor may occasionally change your dose to make sure you get the best results from this medication.
  • Take Slow Zem with a full glass of water. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.
  • It is important to use Slow Zem regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • Do not stop taking this medication without first talking to your doctor. If you stop taking Slow Zem suddenly, your condition may become worse.
  • If you are being treated for high blood pressure, keep using this medication even if you feel fine. 
  • If you miss a dose of Slow Zem, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Slow Zem.

STORAGE

Store Slow Zem at room temperature away from moisture and heat. Keep Slow Zem out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Diltiazem.

SAFETY INFORMATION

Do NOT use Slow Zem if:

  • you are allergic to any ingredient in Slow Zem
  • you have sick sinus syndrome or have second- or third-degree heart block and do not have a pacemaker, or very low blood pressure
  • you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White syndrome (WPW) or Lown-Ganong-Levine syndrome (LGL)
  • you are receiving injectable beta-blockers (eg, metoprolol) or erythromycin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Slow Zem. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart failure or have had a recent heart attack with lung congestion, heart block, low blood pressure, a very slow heart rate, or abnormal heart rhythm
  • if you have kidney or liver disease.

Some medicines may interact with Slow Zem. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cimetidine or protease inhibitors (eg, indinavir) because they may increase the actions and side effects of Slow Zem
  • Rifampin because it may decrease the effectiveness of Slow Zem
  • Amiodarone, cisapride, digoxin, erythromycin, protease inhibitors (eg, indinavir), quinidine, tricyclic antidepressants (eg, desipramine), theophylline, or general anesthetics because toxic effects on the heart may occur
  • Benzodiazepines (eg, midazolam), beta-blockers (eg, metoprolol), buspirone, carbamazepine, cilostazol, corticosteroids (eg, prednisone), cyclosporine, HMG-CoA reductase inhibitors (eg, atorvastatin), macrolide immunomodulators (eg, tacrolimus) because the risk of their side effects, some potentially life-threatening, may be increased by Slow Zem.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Slow Zem may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Slow Zem may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Slow Zem with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Slow Zem may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Slow Zem may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Slow Zem. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Slow Zem before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including electrocardiogram (ECG), heart rate, and blood pressure monitoring, may be performed while you use Slow Zem. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Slow Zem with caution in the elderly; they may be more sensitive to its effects.
  • Slow Zem should not be used in children; safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Slow Zem while you are pregnant. Slow Zem is found in breast milk. Do not breastfeed while taking Slow Zem.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; dizziness; facial flushing; headache; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); hallucinations; irregular heartbeat; swelling of the feet or hands; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools); tender, bleeding, or swollen gums.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Para no experimentar las reacciones no deseadas y los efectos secundarios hemos de tener en cuenta las contraindicaciones, advertencias y las precauciones. Aun así, algunos pacientes hipersensibles podrían experimentar reacciones negativas de diferente grado que vamos a enumerar. Busque asistencia médica sin hesitar en el momento en que haya notado los siguientes efectos secundarios que enumeraremos más abajo y póngase en contacto con algún médico o especialista médico online para eliminar el riesgo de consecuencias graves:

More Common

  • Body aches or pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • runny nose
  • tender or swollen glands in the neck
  • trouble swallowing
  • voice changes
  • Sneezing
  • stuffy nose

Less Common

  • Chest pain or discomfort
  • chills
  • diarrhea
  • difficult or labored breathing
  • feeling faint, dizzy, or lightheaded
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • shivering
  • slow or irregular heartbeat
  • sweating
  • swelling of the hands, ankles, feet, or lower legs
  • tightness in the chest
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
  • Acid or sour stomach
  • belching
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • degenerative disease of the joint
  • difficulty with moving
  • hearing loss
  • heartburn
  • indigestion
  • lack or loss of strength
  • muscle aching or cramping
  • muscle pains or stiffness
  • pain or tenderness around the eyes and cheekbones
  • rash
  • stomach discomfort, upset, or pain
  • swollen joints

Incidence Not Known

  • Blistering, peeling, or loosening of the skin
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • no heartbeat
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sores, ulcers, or white spots in the mouth or on the lips
  • Hair loss or thinning of the hair
Type Small Molecule
Accession Number DB00343  (APRD00473)
Groups Approved, Investigational
Synonyms
  • (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
  • (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
  • Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
  • D-cis-diltiazem
  • Diltiazem
  • Diltiazemum
UNII EE92BBP03H
CAS number 42399-41-7
Weight Average: 414.518
Monoisotopic: 414.16132802
Chemical Formula C22H26N2O4S
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
IUPAC Name
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
Protein binding

70%-80%

Toxicity

LD50=740mg/kg (orally in mice)

Half life

3.0 - 4.5 hours

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