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Stugil (Brand name: Motilium)

  • €0.23
  • Brand name: Motilium
  • Disponibilidad: En stock
  • Ingrediente activo: domperidone
Stugil es utilizado para detener náuseas y vómitos en adultos y niños. Es utilizado también para aliviar el malestar estomacal, sensación de llenura o timpanitis y regurgitación del contenido del estómago (reflujo o pirosis) en los adultos.
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10 mg
Nombre del producto Por píldora Por paquete  
90 píldoras €0.30 €27.14
180 píldoras €0.25 €54.28 €45.59
270 píldoras €0.24 €81.42 €64.06
360 píldoras €0.23 €108.57 €82.52

INDICATIONS

Stugil is indicated for:

-         delayed gastric emptying of functional origin with gastro-oesophageal reflux and/or dyspepsia;

-         control of nausea and vomiting of central or local origin;

-         as an anti-emetic in patients receiving cytostatic and radiation therapy;

-         facilitates radiological examination of the upper gastro-intestinal tract.

 INSTRUCTIONS 

Use Stugil as directed by your doctor.

  • Take Stugil by mouth before meals.
  • If you miss a dose of Stugil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

DOSAGE

Acute conditions (mainly nausea, vomiting, hiccup)

Adults: Two tablets (20 mg) 3 to 4 times per day, 15 to 30 minutes before meals and, if necessary, before retiring.
Children 5 to 12 years old: One tablet (10 mg) 3 to 4 times per day, 15 to 30 minutes before meals and, if necessary, before retiring.

Chronic conditions (mainly dyspepsia)

Adults: One tablet (10 mg) taken 3 times per day, 15 to 30 minutes before meals and, if necessary, before retiring. The dosage may be doubled.
 Children 5 to 12 years: ½ tablet (5 mg) 3 to 4 times per day, 15 to 30 minutes before meals and if necessary, before retiring.

This formulation is not suited for children under the age of 5 years, but for this group of patients the suspension is available. Stugil tablets are not suitable for children weighing less than 35kg.

Stugil should be used with caution in patients with renal impairment or in those at risk of fluid retention. In patients with severe renal insufficiency ( serum creatinine more than 6 mg/100 mL, ie. more than 0,6 mmol/L) the elimination half-life of domperidone was increased from 7,4 to 20,8 hours. The dosing frequency should be reduced to once or twice daily, depending on the severity of impairment, and the dose may need to be reduced. Patients on prolonged therapy should be reviewed regularly.

Ask your health care provider any questions you may have about how to use Stugil.

STORAGE

Store Stugil between 68 and 77 degrees F (20 and 25 degrees C). Protect from heat, light, and moisture. Do not store in the bathroom. Keep Stugil out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Domperidone.

Stugil tablets contain lactose and may be unsuitable for people with lactose intolerance, glucose/galactose malabsorption or a genetic disorder leading to accumulation of galactose in the blood (galactosaemia).

SAFETY INFORMATION

Do NOT use Stugil if:

  • you are allergic to any ingredient in Stugil
  • you are pregnant, planning to become pregnant, or become pregnant while taking Stugil
  • you are breast-feeding.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Stugil. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances.

Not to be used in

  • Cancer of the pituitary gland resulting in over-production of the hormone prolactin (prolactinoma).
  • Conditions in which stimulating movement through the stomach could be harmful, for example if there is bleeding, an abnormal hole (perforation) or a blockage in the stomach or intestines.
  • Decreased liver function.

Some medicines may interact with Stugil. Tell your health care provider if you are taking any other medicines. The following medicines may oppose the stimulating effect of domperidone on the gut and so could make it less effective:

  • antimuscarinic medicines, such as antispasmodics (eg atropine, hyoscine, propantheline), medicines for urinary incontinence (eg oxybutynin, flavoxate, tolterodine, propiverine, trospium), or antimuscarinics for Parkinson's (eg procyclidine, trihexyphenidyl, orphenadrine)
  • strong opioid painkillers, eg morphine, codeine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Stugil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • The safety of this medicine for use during pregnancy has not been established. It should not be used in pregnant women unless the potential benefits to the mother outweigh any risks to the developing baby. It should only be used if the medicine is considered essential by your doctor.  
  • This medicine passes into breast milk in very small amounts that are not expected to be harmful to a nursing infant. However, the medicine is not recommended for use in women who are breastfeeding unless the potential benefit to the mother outweighs any risks to the nursing infant.

SIDE EFFECTS

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Rare (affect between 1 in 1000 and 1 in 10,000 people)

  • Increased level of prolactin (milk producing hormone) in the blood (hyperprolactinaemia). Sometimes this can lead to symptoms such as abnormal enlargement of breasts in men (gynaecomastia), abnormal production of breast milk in men and women, or stopping of menstrual periods in women.
  • Decreased sex drive in men.

Very rare (affect less than 1 in 10,000 people)

  • Stomach cramps.
  • Diarrhoea.
  • Itchy nettle-type rash (urticaria).
  • Abnormal or uncontrolled movements of the hands, legs, face, eyes, neck or tongue, for example tremor, twitching or stiffness (extrapyramidal effects). Consult a doctor straight away if you notice any symptoms like this.
  • Allergic reaction.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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    Malo           Bueno
Type Small Molecule
Accession Number DB01184  (APRD00418)
Groups Approved, Investigational, Vet approved
Synonyms
  • 1-(3-(4-(5-chloro-2-oxo-2,3-Dihydrobenzo[D]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[D]imidazol-2(3H)-one
  • 5-chloro-1-(1-(3-(2-oxo-1-Benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
  • 5-chloro-1-(1-(3-(2-oxo-2,3-Dihydrobenzo[D]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[D]imidazol-2(3H)-one
  • 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
  • Domperidona
  • Domperidonum
UNII 5587267Z69
CAS number 57808-66-9
Weight Average: 425.911
Monoisotopic: 425.161852744
Chemical Formula C22H24ClN5O2
InChI
InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
IUPAC Name
5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
Protein binding

91%-93%

Toxicity

Side effects include galactorrhea, gynecomastia, or menstrual irregularities.

Half life

7 hours

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