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Sulbenin (Brand name: Aricept)

  • €0.62
  • Brand name: Aricept
  • Disponibilidad: En stock
  • Ingrediente activo: Donepezil
Sulbenin es utilizado para el tratamiento de la demencia (por ejemplo, el deterioro de la memoria, juicio, pensamiento abstracto, cambios de la personalidad) en pacientes con enfermedad de Alzheimer.
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10 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.02 €30.64
60 píldoras €0.77 €61.28 €46.23
90 píldoras €0.69 €91.91 €61.83
120 píldoras €0.65 €122.55 €77.43
180 píldoras €0.60 €183.83 €108.63
270 píldoras €0.58 €275.74 €155.41
360 píldoras €0.56 €367.65 €202.22
5 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €0.93 €27.86
60 píldoras €0.76 €55.71 €45.68
90 píldoras €0.71 €83.57 €63.51
120 píldoras €0.68 €111.42 €81.34
180 píldoras €0.65 €167.13 €117.00
270 píldoras €0.63 €250.70 €170.47
360 píldoras €0.62 €334.27 €223.96

INDICATIONS

Sulbenin is used for treating dementia (eg, impairment of memory, judgment, and abstract thinking; changes in personality) in patients with Alzheimer disease. Sulbenin is a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain, which may help reduce the symptoms of dementia in patients with Alzheimer disease.

INSTRUCTIONS 

Use Sulbenin as directed by your doctor.

  • Take Sulbenin by mouth in the evening right before bed, unless your doctor tells you otherwise. Take Sulbenin with or without food.
  • Take Sulbenin on a regular schedule to get the most benefit from it.
  • Taking Sulbenin at the same time each day will help you remember to take it.
  • Continue to take Sulbenin even if you feel well. Do not miss any dose.
  • If you miss a dose of Sulbenin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Contact your doctor if you miss several doses of Sulbenin. You may need to restart your medicine at a lower dose to avoid side effects.

Ask your health care provider any questions you may have about how to use Sulbenin.

STORAGE

Store Sulbenin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Sulbenin out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Donepezil.

SAFETY INFORMATION

Do NOT use Sulbenin if:

  • you are allergic to any ingredient in Sulbenin.

Some medical conditions may interact with Sulbenin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of certain heart problems (eg, slow or irregular heartbeat, sick sinus syndrome), stomach or bowel problems (eg, ulcer, blockage), lung or breathing problems (eg, asthma, chronic obstructive pulmonary disease [COPD]), or urinary blockage
  • if you have brain lesions or tumors, increased pressure in the brain, recent head injury, or a history of seizures (eg, epilepsy)
  • if you have Parkinson disease or metabolism problems.

Some medicines may interact with Sulbenin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of stomach or bowel bleeding may be increased
  • Cholinergic agents (eg, bethanechol), cholinesterase inhibitors (eg, galantamine), or ketoconazole because they may increase the risk of Sulbenin's side effects
  • Carbamazepine, dexamethasone, phenobarbital, phenytoin, or rifampin because they may decrease Sulbenin's effectiveness
  • Anticholinergics (eg, scopolamine) because their effectiveness may be decreased by Sulbenin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sulbenin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Sulbenin may cause drowsiness, dizziness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Sulbenin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not take more than the recommended dose without checking with your doctor.
  • Tell your doctor or dentist that you take Sulbenin before you receive any medical or dental care, emergency care, or surgery.
  • Sulbenin is not approved for use in children; safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sulbenin while you are pregnant. It is not known if Sulbenin is found in breast milk. Sulbenin is not approved for use in women who may be breast-feeding.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Abnormal dreams; diarrhea; dizziness; loss of appetite; muscle cramps; nausea; tiredness; trouble sleeping; vomiting; weight loss.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; chest pain; decreased urination; depression; fainting; fever; seizures; severe dizziness or headache; shortness of breath; slow or irregular heartbeat; swelling of the hands, ankles, or feet; unusual bruising; tremor.

 This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Para no experimentar las reacciones no deseadas y los efectos secundarios hemos de tener en cuenta las contraindicaciones, advertencias y las precauciones. Aun así, algunos pacientes hipersensibles podrían experimentar reacciones negativas de diferente grado que vamos a enumerar. Busque asistencia médica sin hesitar en el momento en que haya notado los siguientes efectos secundarios que enumeraremos más abajo y póngase en contacto con algún médico o especialista médico online para eliminar el riesgo de consecuencias graves:

Rare

  • Black, tarry stools
  • bloating
  • bloody or cloudy urine
  • blurred vision
  • burning, prickling, or tingling sensations
  • cataract
  • chills
  • clumsiness or unsteadiness
  • confusion
  • cough
  • decreased urination
  • difficult or painful urination
  • dryness of mouth
  • eye irritation
  • fever
  • flushing of skin
  • frequent urge to urinate
  • high or low blood pressure
  • hives
  • hot flashes
  • increase in sexual desire or performance
  • increased heart rate and breathing
  • increased sweating
  • increased urge to urinate during the night
  • irregular heartbeat
  • itching
  • loss of bladder control
  • loss of bowel control
  • mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness
  • nasal congestion
  • pain in chest, upper stomach, or throat
  • problems with speech
  • runny nose
  • severe thirst
  • shortness of breath
  • sneezing
  • sore throat
  • sunken eyes
  • tightness in chest
  • tremor
  • troubled breathing
  • wheezing
  • wrinkled skin

More Common

  • Diarrhea
  • loss of appetite
  • muscle cramps
  • nausea
  • trouble in sleeping
  • unusual tiredness or weakness
  • vomiting

Less Common

  • Abnormal dreams
  • constipation
  • dizziness
  • drowsiness
  • fainting
  • frequent urination
  • headache
  • joint pain, stiffness, or swelling
  • mental depression
  • pain
  • unusual bleeding or bruising
  • weight loss

Incidence Not Known

  • Back, leg, or stomach pains
  • bleeding gums
  • chest pain or discomfort
  • coma
  • convulsions
  • dark urine
  • difficulty breathing
  • fast or irregular heartbeat
  • fatigue
  • general body swelling
  • general tiredness and weakness
  • high fever
  • increased thirst
  • indigestion
  • light-colored stools
  • muscle pain or cramps
  • nausea and vomiting
  • nosebleeds
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • rash
  • seeing, hearing, or feeling things that are not there
  • seizures
  • severe muscle stiffness
  • severe nausea
  • slow or irregular heartbeat
  • stomach pain
  • sweating
  • swelling of face, ankles, or hands
  • tiredness
  • unusually pale skin
  • upper right abdominal or stomach pain
  • yellow eyes and skin
Type Small Molecule
Accession Number DB00843  (APRD00039)
Groups Approved
Synonyms
  • Domepezil
  • Donepezil
  • Donepezilo
  • Donepezilum
UNII 8SSC91326P
CAS number 120014-06-4
Weight Average: 379.492
Monoisotopic: 379.214743799
Chemical Formula C24H29NO3
InChI
InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
IUPAC Name
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
Protein binding

96%

Toxicity

Symptoms of overdose include severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved.

Half life

70 hours

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