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Savarine (Brand name: Chloroquine)

  • €0.85
  • Brand name: Chloroquine
  • Disponibilidad: En stock
  • Ingrediente activo: Chloroquine
Savarine es un medicamento utilizado para prevenir y tratar la malaria, una infección de los glóbulos rojos transmitida por la picadura de un mosquito, y para el tratamiento de algunas condiciones tales como enfermedad del hígado causada por protozoarios (pequeños animales unicelulares).
Otros nombres de Savarine (Brand name: Chloroquine): Plaquenil  
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Avloquin   Avloclor   Arechin   Aralen   Aloquin   Alexoquine   Aralen   Arechin   Avloclor   Avloquin   Savarine  
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250 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.20 €36.09
60 píldoras €1.00 €72.17 €60.28
90 píldoras €0.94 €108.26 €84.47
120 píldoras €0.91 €144.34 €108.66
180 píldoras €0.87 €216.52 €157.04
270 píldoras €0.85 €324.77 €229.61

INDICATIONS

Savarine is indicated for the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated for the treatment of extraintestinal amebiasis.

INSTRUCTIONS

Take chloroquine with meals or milk to lessen stomach upset, unless otherwise directed by your doctor.

t is very important that you take chloroquine only as directed. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of serious side effects.

If you are taking chloroquine to help keep you from getting malaria, keep taking it for the full time of treatment. If you already have malaria, you should still keep taking chloroquine for the full time of treatment even if you begin to feel better after a few days. This will help to clear up your infection completely. If you stop taking chloroquine too soon, your symptoms may return.

Savarine works best when you take it on a regular schedule. For example, if you are to take it once a week to prevent malaria, it is best to take it on the same day each week. Or if you are to take two doses a day, one dose may be taken with breakfast and the other with the evening meal. Make sure that you do not miss any doses. If you have any questions about this, check with your health care professional.

If you miss a dose of chloroquine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

DOSAGE 

The dosage of chloroquine phosphate is often expressed in terms of equivalent chloroquine base. Each 500 mg tablet of ARALEN contains the equivalent of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body weight.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on exactly the same day of each week.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of body weight, but should not exceed the adult dose regardless of weight.

If circumstances permit, suppressive therapy should begin two weeks prior to exposure. However, failing this in adults, an initial double (loading) dose of 1 g (= 600 mg base), or in children 10 mg base/kg may be taken in two divided doses, six hours apart. The suppressive therapy should be continued for eight weeks after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of 1 g (= 600 mg base) followed by an additional 500 mg (= 300 mg base) after six to eight hours and a single dose of 500 mg (= 300 mg base) on each of two consecutive days. This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days.

The dosage for adults of low body weight and for infants and children should be determined as follows:

First dose: 10 mg base per kg (but not exceeding a single dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (but not exceeding a single dose of 300 mg base).

Third dose: (24 hours after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy with an 8-aminoquinoline compound is necessary.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for two days, followed by 500 mg (300 mg base) daily for at least two to three weeks. Treatment is usually combined with an effective intestinal amebicide.

STORAGE 

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

SAFETY INFORMATION

If you will be taking chloroquine for a long time, it is very important that your doctor check you at regular visits for any blood problems or muscle weakness that may be caused by chloroquine. In addition, check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

Make sure you know how you react to chloroquine before you drive, use machines, or do anything else that could be dangerous if you are not able to see well.

Savarine may cause blurred vision, difficulty in reading, or other change in vision. It may also cause some people to become lightheaded.

If these reactions are especially bothersome, check with your doctor.

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women. Usage of chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the potential risk to the fetus.

SIDE EFFECTS

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. When chloroquine is used for short periods of time, side effects usually are rare. However, when it is used for a long time and/or in high doses, side effects are more likely to occur and may be serious.

Check with your doctor immediately if any of the following side effects occur:
Less common

Blurred vision
change in vision
eye pain
loss of vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood or other mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any loss of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The side effects in the Less Common category above may also occur or get worse after you stop taking chloroquine.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common


Diarrhea
difficulty in seeing to read
headache
itching (more common in black patients)
loss of appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or inside of mouth
skin rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

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Para no experimentar las reacciones no deseadas y los efectos secundarios hemos de tener en cuenta las contraindicaciones, advertencias y las precauciones. Aun así, algunos pacientes hipersensibles podrían experimentar reacciones negativas de diferente grado que vamos a enumerar. Busque asistencia médica sin hesitar en el momento en que haya notado los siguientes efectos secundarios que enumeraremos más abajo y póngase en contacto con algún médico o especialista médico online para eliminar el riesgo de consecuencias graves:

Incidence Not Known

  • Change in hair color
  • hair loss
  • increased sensitivity of the skin to sunlight
  • redness or other discoloration of the skin
  • severe sunburn
  • stomach cramps
  • trouble sleeping
  • weight loss
Type Small Molecule
Accession Number DB00608  (APRD00468)
Groups Approved, Investigational, Vet approved
Synonyms
  • Chloraquine
  • Chlorochin
  • Chloroquina
  • Chloroquine
  • Chloroquinium
  • Chloroquinum
  • Cloroquina
  • N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine
UNII 886U3H6UFF
CAS number 54-05-7
Weight Average: 319.872
Monoisotopic: 319.181525554
Chemical Formula C18H26ClN3
InChI
InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)
IUPAC Name
7-chloro-N-[5-(diethylamino)pentan-2-yl]quinolin-4-amine
Protein binding

~55% of the drug in the plasma is bound to nondiffusible plasma constituents

Toxicity Not Available
Half life

1-2 months

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