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Signelon (Brand name: Exelon)

  • €0.49
  • Brand name: Exelon
  • Disponibilidad: En stock
  • Ingrediente activo: Rivastigmine
Signelon es utilizado para tratar la demencia leve a moderada (por ejemplo, el empeoramiento de la memoria o de juicio, pensamiento abstracto, cambios en la personalidad) en pacientes con enfermedad de Alzheimer o la enfermedad de Parkinson.
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Altigmin   Signelon  
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6 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.32 €39.66
60 píldoras €1.03 €79.32 €61.92
90 píldoras €0.94 €118.98 €84.18
120 píldoras €0.89 €158.64 €106.44
180 píldoras €0.84 €237.96 €150.95
270 píldoras €0.81 €356.94 €217.73
4.5 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.19 €35.71
60 píldoras €0.94 €71.42 €56.23
90 píldoras €0.85 €107.14 €76.75
120 píldoras €0.81 €142.85 €97.27
180 píldoras €0.77 €214.27 €138.31
270 píldoras €0.74 €321.41 €199.86
360 píldoras €0.73 €428.55 €261.43
3 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.15 €34.46
60 píldoras €0.90 €68.93 €54.27
90 píldoras €0.82 €103.39 €74.07
120 píldoras €0.78 €137.86 €93.87
180 píldoras €0.74 €206.79 €133.47
270 píldoras €0.71 €310.18 €192.87
360 píldoras €0.70 €413.57 €252.29
1.5 mg
Nombre del producto Por píldora Por paquete  
60 píldoras €0.86 €51.50
90 píldoras €0.71 €77.25 €63.97
180 píldoras €0.56 €154.50 €101.35
270 píldoras €0.51 €231.76 €138.74
360 píldoras €0.49 €309.01 €176.14

INDICATIONS

Signelon is used for treating mild to moderate dementia (eg, impairment of memory or judgement, abstract thinking, changes in personality) in patients with Alzheimer disease or Parkinson disease. Signelon is a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain. This may help reduce symptoms of dementia in patients with Alzheimer disease.

INSTRUCTIONS 

Use Signelon as directed by your doctor.

  • Take Signelon by mouth with the morning and evening meals, unless your doctor tells you otherwise.
  • Take Signelon on a regular schedule to get the most benefit from it.
  • Taking Signelon at the same time each day will help you remember to take it.
  • Continue to take Signelon even if you feel well. Do not miss any doses.
  • If you miss a dose of Signelon, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Contact your doctor if you miss several doses of Signelon. Your doctor may need to restart your medicine at a lower dose to avoid side effects.

Ask your health care provider any questions you may have about how to use Signelon.

STORAGE

Store Signelon at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Signelon out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Rivastigmine tartrate.

SAFETY INFORMATION

Do NOT use Signelon if:

  • you are allergic to any ingredient in Signelon.

Some medical conditions may interact with Signelon. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney problems, certain heart problems (eg, slow or irregular heartbeat, sick sinus syndrome), seizures (eg, epilepsy), stomach or bowel problems (eg, ulcer), lung or breathing problems (eg, asthma, chronic obstructive pulmonary disease [COPD]), or urinary blockage
  • if you have dementia or other decreased mental ability that is not caused by Alzheimer disease or Parkinson disease
  • if you are scheduled to have surgery or other medical procedures with general anesthesia.

Some medicines may interact with Signelon. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of stomach or bowel bleeding may be increased
  • Cholinergic agents (eg, bethanechol) or cholinesterase inhibitors (eg, donepezil) because they may increase the risk of Signelon's side effects
  • Anticholinergics (eg, scopolamine) because their effectiveness may be decreased by Signelon.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Signelon may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Signelon may cause dizziness, drowsiness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Signelon with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not take more than the recommended dose without checking with your doctor.
  • When you begin taking Signelon, your doctor will increase your dose slowly over several months. This may help to decrease the risk of certain side effects (eg, nausea, vomiting, loss of appetite). Carefully follow the dosing schedule prescribed by your doctor.
  • Tell your doctor or dentist that you take Signelon before you receive any medical or dental care, emergency care, or surgery.
  • Signelon should not be used in children; safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Signelon while you are pregnant. It is not known if Signelon is found in breast milk. Signelon is not approved for use in women who may be breast-feeding.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; headache; increased sweating; loss of appetite; nausea; stomach upset or pain; tiredness; vomiting; weakness; weight loss.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; bloody or black, tarry stools; chest pain; decreased urination; depression; fainting; fever; new or worsening tremor or uncontrolled muscle movements; new or worsening trouble walking; seizures; severe or persistent dizziness, tiredness, or weakness; slow or irregular heartbeat.

 This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Para no experimentar las reacciones no deseadas y los efectos secundarios hemos de tener en cuenta las contraindicaciones, advertencias y las precauciones. Aun así, algunos pacientes hipersensibles podrían experimentar reacciones negativas de diferente grado que vamos a enumerar. Busque asistencia médica sin hesitar en el momento en que haya notado los siguientes efectos secundarios que enumeraremos más abajo y póngase en contacto con algún médico o especialista médico online para eliminar el riesgo de consecuencias graves:

Rare

  • Aggression
  • convulsions (seizures)
  • trembling and shaking of the hands and fingers
  • trouble urinating

More Common

  • Diarrhea
  • indigestion
  • loss of appetite
  • loss of strength
  • nausea and vomiting
  • weight loss
  • Abdominal or stomach pain or cramping
  • bloated or full feeling
  • confusion
  • dizziness
  • headache
  • mental depression
  • seeing, hearing, or feeling things that are not there
  • trouble sleeping

Less Common

  • Fainting
  • General feeling of discomfort or illness
  • runny nose

Incidence Not Known

  • Bloody or black, tarry stools
  • chest pain or discomfort
  • constipation
  • difficulty with speaking
  • drooling
  • lightheadedness, dizziness, or fainting
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • restlessness
  • severe stomach pain
  • shortness of breath
  • shuffling walk
  • slow or irregular heartbeat
  • stiffness of the limbs
  • trouble urinating
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unusual tiredness
  • vomiting of blood or material that looks like coffee grounds
Type Small Molecule
Accession Number DB00989  (APRD00321)
Groups Approved, Investigational
Synonyms
  • (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
  • m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
UNII PKI06M3IW0
CAS number 123441-03-2
Weight Average: 250.3367
Monoisotopic: 250.168127958
Chemical Formula C14H22N2O2
InChI
InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1
IUPAC Name
3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate
Protein binding

40%

Toxicity Not Available
Half life

1.5 hours

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