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Sheng Jun (Brand name: Isoniazid)

  • €0.32
  • Brand name: Isoniazid
  • Disponibilidad: En stock
  • Ingrediente activo:
Sheng Jun es usado para tratar o prevenir la tuberculosis.
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300 mg
Nombre del producto Por píldora Por paquete  
60 píldoras €0.48 €28.95
90 píldoras €0.42 €43.43 €37.52
120 píldoras €0.38 €57.90 €46.09
180 píldoras €0.35 €86.85 €63.23
270 píldoras €0.33 €130.28 €88.94
360 píldoras €0.32 €173.71 €114.64

INDICATIONS

Sheng Jun is used for treating or preventing tuberculosis (TB). If you are using Sheng Jun to treat TB, it should always be used along with another medicine. Sheng Jun is an antibacterial. It works by killing TB organisms.soniazid also has an antidepressant effect, and it was one of the first antidepressants discovered. Sheng Jun can also be used in the treatment of a BCG-oma.

INSTRUCTIONS 

Use Sheng Jun as directed by your doctor.

  • Take each dose with a full glass (8 ounces) of water.
  • Take Sheng Jun on an empty stomach 1 hour before or 2 hours after meals. If nausea occurs, ask your doctor if you can take Sheng Jun with food.
  • Take all of the Sheng Jun that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.
  • It is important to take Sheng Jun regularly to get the most benefit.
  • Your doctor may also want you to take a supplemental vitamin B6 (pyridoxine) tablet daily during treatment to prevent numbness and tingling caused by low levels of this vitamin.
  • Your doctor may want you to have blood tests or other medical evaluations during treatment with isoniazid to monitor progress and side effects.
  • Continue to use Sheng Jun even if you feel well. Do not miss any dose.
  • If you miss a dose of Sheng Jun, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Sheng Jun.

STORAGE

 Store Sheng Jun between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Sheng Jun out of the reach of children and away from pets.


SAFETY INFORMATION

Do NOT use Sheng Jun if:

  • you are allergic to any ingredient in Sheng Jun or have had severe side effects from isoniazid, such as drug fever, chills, or arthritis
  • you have severe liver damage, active liver disease, or liver damage from previous use of Sheng Jun
  • you have a history of hepatitis caused by any medicine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Sheng Jun. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have diabetes, kidney problems, nerve problems (eg, neuropathy) or risk of nerve problems, HIV, or a history of liver problems
  • if you have a history of alcohol or other substance abuse, have unsanitary injectable drug habits, or drink alcohol daily
  • if you are older than 35 years old, you have recently given birth, or you have previously taken Sheng Jun.

Some medicines may interact with Sheng Jun. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Acetaminophen, anticoagulants (eg, warfarin), carbamazepine, hydantoins (eg, phenytoin), rifampin, theophylline, or valproic acid because the risk of their side effects may be increased by Sheng Jun
  • Ketoconazole because its effectiveness may be decreased by Sheng Jun.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sheng Jun may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Check with your doctor before drinking alcohol while using Sheng Jun. Alcohol may increase the risk of liver problems. If you have a history of alcohol abuse, you may also be at increased risk of developing nerve problems from Sheng Jun. Notify your doctor if you notice any unusual tingling or numbness in your hands or feet.
  • If you have a history of diabetes, alcohol abuse, or poor nutrition, your doctor may recommend that you also take vitamin B6 while you are taking Sheng Jun. This may help to decrease your risk of nerve problems. Discuss any questions with your doctor.
  • Do not eat foods high in tyramine while you use Sheng Jun. Eating foods high in tyramine (eg, aged cheeses, red wines, beer, certain meats and sausages, liver, sour cream, soy sauce, raisins, bananas, avocados) while you use Sheng Jun may cause severe high blood pressure. Seek medical attention at once if symptoms of severe high blood pressure occur. These may include severe headache, fast or irregular heartbeat, sore or stiff neck, nausea, vomiting, sweating, enlarged pupils, or sensitivity to light.
  • Do not eat foods high in histamine while you use Sheng Jun. Eating foods high in histamine (eg, skipjack, tuna, tropical fish) while you use Sheng Jun may cause low blood pressure, irregular heartbeat, headache, sweating, or flushing. Contact your doctor at once if any of these symptoms occur.
  • Ask your health care provider for a complete list of all foods you should avoid while you are using Sheng Jun.
  • Sheng Jun only works against TB bacteria; it does not treat viral infections (eg, the common cold).
  • Be sure to use Sheng Jun for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Diabetes patients - Sheng Jun may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. You may also be at increased risk of developing nerve problems from Sheng Jun. Contact your doctor if you notice any unusual tingling in your hands or feet.
  • Lab tests, including liver function and eye exams, may be performed while you use Sheng Jun. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Sheng Jun with caution in black and Hispanic women; they may have a greater risk of severe liver problems from Sheng Jun.
  • Use Sheng Jun with caution in patients older 35 years; they may have a greater risk of severe liver problems from Sheng Jun.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sheng Jun while you are pregnant. Sheng Jun is found in breast milk. If you are or will be breast-feeding while you use Sheng Jun, check with your doctor. Discuss any possible risks to your baby.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Mild stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; chills or fever; dark urine; general feeling of discomfort; increased thirst or urination; joint pain or swelling; loss of appetite; memory problems; mental or mood changes; nausea; seizures; stomach pain or tenderness; symptoms of low vitamin B6 levels (eg, confusion, cracks in the corners of the mouth, irritability, mouth redness or soreness, scaly rash); tingling or numbness in the hands or feet; unusual bruising or bleeding; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.
 This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Para no experimentar las reacciones no deseadas y los efectos secundarios hemos de tener en cuenta las contraindicaciones, advertencias y las precauciones. Aun así, algunos pacientes hipersensibles podrían experimentar reacciones negativas de diferente grado que vamos a enumerar. Busque asistencia médica sin hesitar en el momento en que haya notado los siguientes efectos secundarios que enumeraremos más abajo y póngase en contacto con algún médico o especialista médico online para eliminar el riesgo de consecuencias graves:

Rare

  • Blurred vision or loss of vision, with or without eye pain
  • convulsions (seizures)
  • fever and sore throat
  • joint pain
  • mental depression
  • mood or other mental changes
  • skin rash
  • unusual bleeding or bruising

More Common

  • Diarrhea
  • stomach pain
Type Small Molecule
Accession Number DB00951  (APRD01055, EXPT01940)
Groups Approved, Investigational
Synonyms
  • 4-pyridinecarbohydrazide
  • INH
  • Isoniazid
  • Isonicotinic acid hydrazide
  • Isonicotinic hydrazide
  • Isonicotinohydrazide
  • Isonicotinoylhydrazide
  • Isonicotinsaeurehydrazid
  • Isonicotinylhydrazine
  • Pyridine-4-carboxylic acid hydrazide
UNII V83O1VOZ8L
CAS number 54-85-3
Weight Average: 137.1393
Monoisotopic: 137.058911861
Chemical Formula C6H7N3O
InChI
InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
IUPAC Name
pyridine-4-carbohydrazide
Protein binding

Very low (0-10%)

Toxicity

LD50 100 mg/kg (Human, oral). Adverse reactions include rash, abnormal liver function tests, hepatitis, peripheral neuropathy, mild central nervous system (CNS) effects. In vivo, Isoniazid reacts with pyridoxal to form a hydrazone, and thus inhibits generation of pyridoxal phosphate. Isoniazid also combines with pyridoxal phosphate; high doses interfere with the coenzyme function of the latter.

Half life

Fast acetylators: 0.5 to 1.6 hours. Slow acetylators: 2 to 5 hours.

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