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Sancuso (Brand name: Kytril)

  • €1.54
  • Brand name: Kytril
  • Disponibilidad: En stock
  • Ingrediente activo: Granisetron
Sancuso es utilizado para prevenir las náuseas y los vómitos que pueden ser causados ​​por los medicamentos usados para el tratamiento del cáncer (quimioterapia o radioterapia).
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1 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €2.14 €64.09
60 píldoras €1.80 €128.19 €108.00
90 píldoras €1.69 €192.28 €151.90
120 píldoras €1.63 €256.38 €195.81
180 píldoras €1.58 €384.57 €283.62
270 píldoras €1.54 €576.85 €415.33
2 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €3.05 €91.54
60 píldoras €2.43 €183.07 €145.73
90 píldoras €2.22 €274.61 €199.91
120 píldoras €2.12 €366.15 €254.10
180 píldoras €2.01 €549.22 €362.49

INDICATIONS

Sancuso blocks the actions of chemicals in the body that can trigger nausea and vomiting.

INSTRUCTIONS

Take Sancuso exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Sancuso is usually started up to 1 hour before chemotherapy. Follow your doctor's instructions.

Measure the liquid form of Sancuso with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

If you missed a dose - tell your doctor if you forget to take your dose within 1 hour before chemotherapy. Do not take extra medicine to make up the missed dose.

DOSAGE

Emetogenic Chemotherapy
The recommended adult dosage of oral KYTRIL (granisetron hydrochloride) is 2 mg once daily or 1 mg twice daily. In the 2 mg once-daily regimen, two 1 mg tablets or 10 mL of KYTRIL (granisetron) Oral Solution (2 teaspoonfuls, equivalent to 2 mg of granisetron) are given up to 1 hour before chemotherapy. In the 1 mg twice-daily regimen, the first 1 mg tablet or one teaspoonful (5 mL) of KYTRIL (granisetron) Oral Solution is given up to 1 hour before chemotherapy, and the second tablet or second teaspoonful (5 mL) of KYTRIL (granisetron) Oral Solution, 12 hours after the first. Either regimen is administered only on the day(s) chemotherapy is given. Continued treatment, while not on chemotherapy, has not been found to be useful.

Pediatric Use
Safety and effectiveness in pediatric patients have not been established.

Radiation (Either Total Body Irradiation or Fractionated Abdominal Radiation)
The recommended adult dosage of oral KYTRIL (granisetron) is 2 mg once daily. Two 1 mg tablets or 10 mL of KYTRIL (granisetron) Oral Solution (2 teaspoonfuls, equivalent to 2 mg of granisetron) are taken within 1 hour of radiation.

STORAGE

Store Sancuso at room temperature away from moisture and heat.

SAFETY INFORMATION

You should not use Sancuso if you are allergic to granisetron or to similar medicines such as dolasetron (Anzemet), ondansetron (Zofran), or palonosetron (Aloxi).

Before taking Sancuso, tell your doctor if you have liver disease, a heart rhythm disorder, an electrolyte imbalance (such as low levels of potassium or magnesium in your blood), or a personal or family history of Long QT syndrome.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take Sancuso:

  • liver disease;
  • a heart rhythm disorder;
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
  • a personal or family history of Long QT syndrome.

FDA pregnancy category B. Sancuso is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether granisetron passes into breast milk or if it could harm a nursing baby. Do not use Sancuso without telling your doctor if you are breast-feeding a baby.

Sancuso is usually started up to 1 hour before chemotherapy. Tell your doctor if you forget to take the medication within the specified amount of time before your procedure.

There may be other drugs that can interact with Sancuso. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

SIDE EFFECTS

Get emergency medical help if you have any of these signs of an allergic reaction to Sancuso: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

  • fast or pounding heartbeats;
  • fever, body aches, flu symptoms; or
  • easy bruising or bleeding; unusual weakness.

Less serious Sancuso side effects may include:

  • headache;
  • stomach pain or upset, loss of appetite;
  • diarrhea or constipation;
  • dizziness; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

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Para no experimentar las reacciones no deseadas y los efectos secundarios hemos de tener en cuenta las contraindicaciones, advertencias y las precauciones. Aun así, algunos pacientes hipersensibles podrían experimentar reacciones negativas de diferente grado que vamos a enumerar. Busque asistencia médica sin hesitar en el momento en que haya notado los siguientes efectos secundarios que enumeraremos más abajo y póngase en contacto con algún médico o especialista médico online para eliminar el riesgo de consecuencias graves:

Rare

  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • irregular heartbeat
  • nausea
  • shortness of breath
  • skin rash, hives, and itching
  • sweating

More Common

  • Abdominal or stomach pain
  • diarrhea
  • difficulty having a bowel movement (stool)
  • headache
  • lack or loss of strength
  • unusual tiredness or weakness
  • vomiting

Less Common

  • Blurred vision
  • fever
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • Agitation
  • dizziness
  • drowsiness
  • fear
  • heartburn
  • indigestion
  • sleepiness or unusual drowsiness
  • sour stomach
  • trouble with sleeping
  • unusual taste in the mouth
Type Small Molecule
Accession Number DB00889  (APRD01002)
Groups Approved, Investigational
Synonyms
  • granisétron
  • granisetrón
  • granisetronum
UNII WZG3J2MCOL
CAS number 109889-09-0
Weight Average: 312.417
Monoisotopic: 312.195011409
Chemical Formula C18H24N4O
InChI
InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-
IUPAC Name
1-methyl-N-[(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1H-indazole-3-carboxamide
Protein binding

65%

Toxicity

LD50>2000 mg/kg (rat, oral)

Half life

4-6 hours in healthy patients, 9-12 hours in cancer patients

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