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Sindranol (Brand name: Requip)

  • €0.40
  • Brand name: Requip
  • Disponibilidad: En stock
  • Ingrediente activo: Ropinirole
Sindranol es utilizado para tratar la enfermedad de Parkinson y el síndrome de piernas inquietas (SPI).
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2 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €2.96 €88.93
60 píldoras €2.16 €177.85 €129.83
90 píldoras €1.90 €266.78 €170.74
120 píldoras €1.76 €355.70 €211.64
180 píldoras €1.63 €533.55 €293.44
270 píldoras €1.54 €800.33 €416.17
1 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.86 €55.73
60 píldoras €1.45 €111.46 €87.14
90 píldoras €1.32 €167.19 €118.55
120 píldoras €1.25 €222.93 €149.97
180 píldoras €1.18 €334.39 €212.79
270 píldoras €1.14 €501.58 €307.02
360 píldoras €1.11 €668.78 €401.27
0.5 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.07 €32.14
60 píldoras €0.84 €64.28 €50.26
90 píldoras €0.76 €96.42 €68.37
120 píldoras €0.72 €128.56 €86.49
180 píldoras €0.68 €192.85 €122.72
270 píldoras €0.66 €289.27 €177.06
360 píldoras €0.64 €385.69 €231.42
0.25 mg
Nombre del producto Por píldora Por paquete  
60 píldoras €0.70 €41.80
90 píldoras €0.58 €62.70 €52.16
180 píldoras €0.46 €125.39 €83.26
360 píldoras €0.40 €250.78 €145.47

INDICATIONS

Sindranol is used for treating Parkinson disease and restless leg syndrome (RLS). Sindranol is a dopamine agonist. It works in certain areas of the brain to reduce the symptoms of RLS and Parkinson disease.

INSTRUCTIONS 

Use Sindranol as directed by your doctor.

  • Take Sindranol by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Do not suddenly stop taking Sindranol or change your dose without checking with your doctor. Certain severe side effects (eg, abnormal thinking, confusion, fever, stiff muscles) may occur. If you need to stop Sindranol or add a new medicine, your doctor will gradually lower your dose.
  • If you miss a dose of Sindranol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sindranol.

STORAGE

Store Sindranol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Sindranol out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Ropinirole.

SAFETY INFORMATION

Do NOT use Sindranol if:

  • you are allergic to any ingredient in Sindranol.

Some medical conditions may interact with Sindranol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart problems, high or low blood pressure, liver disease, mental or mood problems, or a sleep disorder
  • if you smoke, drink alcohol, or have a personal or family history of addiction (eg, gambling, alcohol).

Some medicines may interact with Sindranol. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin) because the risk of bleeding may be increased
  • Entacapone or levodopa because the risk of hallucinations may be increased
  • Benzodiazepines (eg, diazepam), medicines for mental or mood problems (eg, antidepressants, antipsychotics), or medicines for sleep (eg, zolpidem) because the risk of severe drowsiness may be increased
  • Estrogens (eg, estradiol), fluvoxamine, or quinolones (eg, ciprofloxacin) because they may increase the risk of Sindranol's side effects
  • Butyrophenones (eg, haloperidol), metoclopramide, omeprazole, phenothiazines (eg, chlorpromazine), or thioxanthenes (eg, thiothixene) because they may decrease Sindranol's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sindranol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Sindranol may cause dizziness, drowsiness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Sindranol with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Sindranol; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Sindranol may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Some people who use Sindranol may experience sudden onset of severe drowsiness or may even fall asleep during normal daily activities (eg, eating, talking, driving). This could occur without warning. If this happens, do not drive, operate machinery, or perform other possibly unsafe tasks while you use Sindranol. Tell your doctor right away.
  • Some people have experienced new, unusual, or increased urges (eg, gambling, sexual urges) while using Sindranol. Tell your doctor right away if you notice such effects.
  • Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Patients with Parkinson disease may have an increased risk of developing a certain type of skin cancer (melanoma). It is not known if Sindranol also increases the risk of melanoma. You may need to have skin exams while you are using Sindranol. Tell your doctor if you notice any unusual skin growths or a change in the appearance of a mole. Discuss any questions or concerns with your doctor.
  • If you are taking Sindranol for RLS, contact your doctor if you experience new or worsening symptoms, especially in the early morning hours.
  • Use Sindranol with caution in elderly patients with Parkinson disease; they may be more sensitive to its effects, especially hallucinations.
  • Sindranol should not be used in children; safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sindranol while you are pregnant. It is not known if Sindranol is found in breast milk. Sindranol may decrease breast milk production. Do not breastfeed while taking Sindranol.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; dizziness; drowsiness; fatigue; headache; increased sweating; lightheadedness; loss of appetite; nausea; sore throat or flu-like symptoms; stomach pain or upset; tiredness; vomiting; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; blood in the urine; blurred vision; chest pain; confusion; decreased coordination; fainting; falling asleep during the daytime or during normal activities (eg, conversations, eating); fast, slow, or irregular heartbeat; hallucinations; impotence; joint stiffness or pain; nightmares; numbness or tingling of the skin; severe or persistent headache or dizziness; shortness of breath; swelling of the arms or legs; uncontrolled muscle movements.

 This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

 This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

 

 

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Para no experimentar las reacciones no deseadas y los efectos secundarios hemos de tener en cuenta las contraindicaciones, advertencias y las precauciones. Aun así, algunos pacientes hipersensibles podrían experimentar reacciones negativas de diferente grado que vamos a enumerar. Busque asistencia médica sin hesitar en el momento en que haya notado los siguientes efectos secundarios que enumeraremos más abajo y póngase en contacto con algún médico o especialista médico online para eliminar el riesgo de consecuencias graves:

Rare

  • Anxiety
  • buzzing or ringing in the ears
  • changes in vision
  • fever
  • headache
  • joint pain
  • loss of bladder control
  • muscle cramps, pain, or spasms
  • nasal congestion
  • runny nose
  • sneezing
  • trouble with swallowing
  • unusual urges

More Common

  • Confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • falling
  • nausea
  • seeing, hearing, or feeling things that are not there (hallucinations)
  • sleepiness or unusual drowsiness
  • swelling of the legs
  • twisting, twitching, or other unusual body movements
  • unusual tiredness or weakness
  • worsening of parkinsonism

Less Common

  • Abdominal or stomach pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine
  • blurred vision
  • burning, pain, or difficulty in urinating
  • chest pain
  • chills
  • cold sweats
  • cough
  • double vision or other eye or vision problems
  • fainting
  • fear or nervousness
  • feeling of constant movement of self or surroundings
  • high or low blood pressure
  • irregular or pounding heartbeat
  • loss of memory
  • mental depression
  • pain
  • pain in the arms or legs
  • pounding in the ears
  • rapid weight gain
  • sensation of spinning
  • slow or fast heartbeat
  • sore throat
  • sweating
  • tightness in chest
  • tingling of the hands or feet
  • tingling, numbness, or prickly feelings
  • trouble in concentrating
  • troubled breathing
  • unusual weight gain or loss
  • vomiting
  • Abnormal dreams
  • acid or sour stomach
  • back pain
  • belching
  • decrease in sexual desire or performance
  • difficulty having a bowel movement (stool)
  • dryness of mouth
  • flushing
  • general feeling of discomfort or illness
  • heartburn or gas
  • hot flashes
  • indigestion
  • loss of appetite
  • tremor
  • weight loss
  • yawning
Type Small Molecule
Accession Number DB00268  (APRD00302)
Groups Approved, Investigational
Synonyms
  • Ropinirol
  • Ropinirolum
UNII 030PYR8953
CAS number 91374-21-9
Weight Average: 260.3746
Monoisotopic: 260.1888634
Chemical Formula C16H24N2O
InChI
InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)
IUPAC Name
4-[2-(dipropylamino)ethyl]-2,3-dihydro-1H-indol-2-one
Protein binding

40% bound to plasma proteins with a blood-to-plasma ratio of 1:1.

Toxicity

Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

Half life

6 hours

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