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Synthyroxine (Brand name: Levothroid)

  • €0.28
  • Brand name: Levothroid
  • Disponibilidad: En stock
  • Ingrediente activo: Levothyroxine
Synthyroxine es utilizado para tratar los niveles bajos de hormona tiroidea.
Otros nombres de Synthyroxine (Brand name: Levothroid): Synthroid  
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Synthyroxine  
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200 mcg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.05 €31.48
60 píldoras €0.72 €62.97 €43.05
90 píldoras €0.61 €94.45 €54.61
120 píldoras €0.55 €125.94 €66.17
180 píldoras €0.50 €188.91 €89.30
270 píldoras €0.46 €283.36 €123.99
360 píldoras €0.44 €377.82 €158.67
100 mcg
Nombre del producto Por píldora Por paquete  
60 píldoras €0.71 €42.50
90 píldoras €0.58 €63.75 €52.28
120 píldoras €0.52 €85.00 €62.04
180 píldoras €0.45 €127.50 €81.59
270 píldoras €0.41 €191.25 €110.93
360 píldoras €0.39 €254.99 €140.23
50 mcg
Nombre del producto Por píldora Por paquete  
60 píldoras €0.49 €29.67
90 píldoras €0.41 €44.51 €36.86
120 píldoras €0.37 €59.35 €44.04
180 píldoras €0.32 €89.02 €58.40
270 píldoras €0.30 €133.53 €79.94
360 píldoras €0.28 €178.04 €101.50

INDICATIONS

Synthyroxine is indicated for the treatment of hypothyroidism as a replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis.

Specific indications include: primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) hypothyroidism and subclinical hypothyroidism. Primary hypothyroidism may result from functional deficiency, primary atrophy, partial or total congenital absence of the thyroid gland, or from the effects of surgery, radiation, or drugs, or without the presence of goiter.

INSTRUCTIONS 

Use Synthyroxine as directed by your doctor.

  • Take Synthyroxine by mouth on an empty stomach at least one-half to one hour before breakfast.
  • Do not take an antacid or a product that has iron or calcium in it within 4 hours of taking Synthyroxine.
  • If the patient is a child or if you cannot swallow the tablet whole, you may crush the correct dose of the medicine. Add the crushed medicine to 1 to 2 teaspoons (5 to 10 mL) of water. Mix well. Use a spoon or dropper to give the medicine as soon as possible. Do not store the mixture for later use. Do not mix crushed tablets in soybean infant formula. Ask your pharmacist if you have any questions.
  • Synthyroxine works best if it is taken at the same time each day.
  • Continue to take Synthyroxine even if you feel well. Do not miss any dose.
  • It may take several weeks before you notice an improvement in your symptoms. Do not stop or change your dose of Synthyroxine without first checking with your doctor.
  • If you miss a dose of Synthyroxine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Synthyroxine.

STORAGE

Store Synthyroxine between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Protect from heat, light, and moisture. Do not store in the bathroom. Keep Synthyroxine out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Levothyroxine.

SAFETY INFORMATION

Do NOT use Synthyroxine if:

  • you are allergic to any ingredient in Synthyroxine
  • you have untreated adrenal gland problems or high thyroid hormone levels
  • you have had a recent heart attack.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Synthyroxine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have trouble swallowing, heart or blood vessel problems (eg, coronary artery disease), high blood pressure, blood clotting or bleeding problems, pernicious anemia, diabetes, bone problems (eg, osteoporosis), fertility problems, pituitary problems, adrenal gland problems, or other thyroid problems
  • if you have problems absorbing nutrition from your stomach or intestines into your body
  • if you had a recent surgery or have an upcoming surgery.

Some medicines may interact with Synthyroxine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for infections, inflammation, aches and pains, nasal congestion, asthma, high blood pressure, irregular heartbeat or other heart problems, blood thinning, mental or mood problems, depression, diabetes, other thyroid problems, high cholesterol, hepatitis, weight loss, heartburn, birth control, hormone replacement therapy, growth hormone deficiency, cancer, seizures), and multivitamin products may interact with Synthyroxine, increasing the risk of side effects or decreasing effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Synthyroxine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • It is important to take Synthyroxine exactly as prescribed. Do not take more than the prescribed dose without checking with your doctor.
  • Tell your doctor or dentist that you take Synthyroxine before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Synthyroxine may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Foods that contain soybean flour (including infant formula), cottonseed meal, walnuts, or dietary fiber may decrease the absorption of Synthyroxine. Tell your doctor if your diet includes any of these foods. Your doctor may need to change your dose of Synthyroxine.
  • Mild hair loss may rarely occur during the first few months of treatment with Synthyroxine. This is usually temporary. Contact your doctor if hair loss is severe or persistent.
  • Lab tests, including thyroid hormone level and growth checks, may be performed while you use Synthyroxine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Synthyroxine with caution in the elderly; they may be more sensitive to its effects, especially heart problems.
  • Children and teenagers may need regular growth checks while they take Synthyroxine.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. Your doctor may need to change your dose of Synthyroxine. Synthyroxine is found in breast milk. If you are or will be breast-feeding while you use Synthyroxine, check with your doctor. Discuss any possible risks to your baby.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

No common side effects have been reported with the use of Synthyroxine.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; flushing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); changes in appetite; changes in menstrual periods; chest pain; diarrhea; excessive sweating; fast or irregular heartbeat; fever; heat intolerance; joint pain; leg cramps; mental or mood changes (eg, anxiety, irritability, nervousness); muscle weakness; seizures; severe or persistent headache or fatigue; shortness of breath; stomach cramps; tremors; trouble sleeping; unusual weight gain or weight loss; vomiting; wheezing.

 This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Para no experimentar las reacciones no deseadas y los efectos secundarios hemos de tener en cuenta las contraindicaciones, advertencias y las precauciones. Aun así, algunos pacientes hipersensibles podrían experimentar reacciones negativas de diferente grado que vamos a enumerar. Busque asistencia médica sin hesitar en el momento en que haya notado los siguientes efectos secundarios que enumeraremos más abajo y póngase en contacto con algún médico o especialista médico online para eliminar el riesgo de consecuencias graves:

Rare

  • Blurred or double vision
  • dizziness
  • eye pain
  • lack or slowing of normal growth in children
  • limp or walk favoring one leg
  • pain in the hip or knee
  • seizures
  • severe headache

Less Common

  • Chest pain or discomfort
  • decreased urine output
  • difficult or labored breathing
  • difficulty with swallowing
  • dilated neck veins
  • extreme fatigue
  • fainting
  • fast, slow, irregular, pounding, or racing heartbeat or pulse
  • fever
  • heat intolerance
  • hives or welts, skin itching, rash, or redness
  • irregular breathing
  • irritability
  • menstrual changes
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • sweating
  • swelling of the eyes, face, lips, throat, or tongue
  • tightness in the chest
  • tremors
  • Abdominal or stomach cramps
  • change in appetite
  • crying
  • diarrhea
  • false or unusual sense of well-being
  • fear or nervousness
  • feeling not well or unhappy
  • feeling of discomfort
  • feeling of warmth
  • feeling things are not real
  • feelings of suspicion and distrust
  • hair loss
  • headache
  • increased appetite
  • mental depression
  • muscle weakness
  • quick to react or overreact emotionally
  • rapidly changing moods
  • redness of the face, neck, arms, and occasionally, upper chest
  • restlessness
  • trouble getting pregnant
  • trouble sitting still
  • unusual tiredness or weakness
  • vomiting
  • weight gain or loss
Type Small Molecule
Accession Number DB00451  (APRD00235, EXPT02993)
Groups Approved
Synonyms
  • 3,3',5,5'-Tetraiodo-L-thyronine
  • 3,5,3',5'-TETRAIODO-L-thyronine
  • 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine
  • L-T4
  • L-Thyroxine
  • Levothyroxin
  • LT4
  • O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine
  • O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
  • T4
UNII Q51BO43MG4
CAS number 51-48-9
Weight Average: 776.87
Monoisotopic: 776.686681525
Chemical Formula C15H11I4NO4
InChI
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
IUPAC Name
(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
Protein binding

> 99% to serum proteins, including thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (TBA)

Toxicity

LD50=20 mg/kg (orally in rat). Hypermetabolic state indistinguishable from thyrotoxicosis of endogenous origin. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and menstrual irregularities.

Half life

T4, 6 to 7 days. T3, 1 to 2 days.

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